Andrew Laine


351 Engineering Terrace
Mail Code 8904 

Tel(212) 854-6539
Fax(212) 854-8725

As director of the Heffner Biomedical Imaging Lab at Columbia, Andrew Laine focuses on the mathematical analysis and quantification of medical images, signal and image processing, computer-aided diagnosis and biomedical / imaging informatics. His work is based on imaging structures at the molecular, cellular, tissue, and organ levels of analysis. The goal is to develop biomedical technology for unmet clinical needs and to transition that technology into commercial products that will improve healthcare and save lives. 

Research Interests

Mathematical analysis and quantification of medical images, signal and image processing, computer-aided diagnosis.

Laine was the first to use multiscale “wavelet” representation to enhance subtle details in mammograms. Today, the algorithm he developed in 1992 is used in almost all commercial digital mammography systems. Currently, Laine is applying multiresolution wavelet techniques to classify pulmonary emphysema. He is also collaborating on a project in medical informatics to enable clinicians to better diagnose a patient using both text and annotated findings from medical images. Laine’s work draws on such techniques as time-frequency decompositions, speckle tracking, texture analysis, variational segmentation, parametric deformable models, and image reconstructions.

Laine received a BS in biological science from Cornell University in 1977, an MS in chemistry from the University of Connecticut in 1980, and a DSc in computer science from Washington University, St. Louis, in 1989. He is a fellow of the Institute of Electrical and Electronics Engineers and of the International Federation for Medical and Biological Engineering. He is also a member of Columbia’s Data Science Institute. 


  • Postdoctoral fellow, Center for Intelligent Computer Systems, Washington University, St. Louis, 1989–1990
  • Research associate, Computer Vision Group, Washington University, St. Louis, 1985–1989
  • Lecturer/research associate, Defense Mapping Agency Professional, Development  Program in Computer Science for Image Processing, Washington University, St. Louis, 1983–1985


  • Chair of biomedical engineering, Columbia University, 2012–
  • Percy K. and Vida W. Hudson Professor of Biomedical Engineering and Professor of Radiology, Columbia University, 2011–
  • Professor of biomedical engineering and radiology (physics), Columbia University, 2004–2010
  • Founding Director, Heffner Biomedical Imaging Lab, Columbia University, 1997–
  • Associate professor of biomedical engineering and radiology (physics), Columbia University, 1995–2004
  • Associate professor of computer and information sciences and engineering; of electrical and computer engineering; and of radiology, University of Florida, 1995–1997
  • Assistant professor of computer and information sciences and engineering, University of Florida, 1990–1995


  • Fellow, Institute of Electrical and Electronics Engineers (IEEE)
  • Fellow, International Federation for Medical and Biological Engineering (IFMBE)
  • Member, Association for Computing Machinery  (ACM)
  • Member, Radiological Society of North America (RSNA)


  • IBM Faculty Award, T.J. Watson Research Center (2008, 2009)
  • Humboldt Research Award, Alexander von Humboldt Foundation, Bonn, Germany;
  • Sponsoring Institutes: Technische Universitat Darmstadt, Darmstadt, Germany, 1998, and University of Bremen, MeVis Institute, Bremen, Germany, 1999
  • Whitaker Foundation Award in Biomedical Engineering, 1992
  • Research Initiation Award, National Science Foundation, 1991
  • Engineering Research Award, Engineering Foundation and the Institute of Electrical and Electronics Engineers, 1991


  • Lorsakul, G.Fakhri, W. Worstell, J. Ouyang, Y. Rakvongthai, A. F. Laine, Q Li, "Numerical observer for atherosclerotic plaque classification in spectral computed tomography." Journal of Medical Imaging,3(3) pp: 035501-035501, 2016.
  • W. Lee, S. Lisanby, A. Laine, A. Peterchev, "Minimum Electric Field Exposure for Seizure Induction with Electroconvulsive Therapy and Magnetic Seizure Therapy". Neuropsychopharmacology, Vol 276, p. 1192, 2016.  (Cover Article, May 2017 - Volume 42, Issue 6)
  • The Journal of the Acoustical Society of America, Volume/Issue: 137/5, pp 2773-2784 (2015)
  • A. Mikhno, F. Zanderigo, R. T. Ogden, J. J. Mann, E. D. Angelini, A. F. Laine, R. V. Parsey, "Toward Noninvasive Quantification of Brain Radioligand Binding by Combining Electronic Health Records and Dynamic PET Imaging Data", IEEE Journal of Biomedical and Health Informatics, Vol. 19, No. 14, pp. 1271-1282, 2015.
  • Lorsakul, Auranuch; El Fakhri, Georges; Guo, Ning; Yen, Ruoh­ Fang; Normandin, Marc D.;     Alpert, Nathaniel M.; Laine, Andrew F.; Li, Quanzheng, "A Numerical     Observer     for Task­Based Assessment on Kinetic Parametric Imaging,” J Nucl Med., 2014: 48.
  • Fei Wang, Noah Lee, Jianying Hu, Jimeng Sun, Shahram Ebadollahi, Andrew F Laine "A Framework for Mining Signatures from Event Sequences and Its Applications in Healthcare Data", IEEE Transactions on Pattern Analysis and Machine Intelligence, 2013
  • Amin Katouzian, Athanasios Karamalis, Abouzar Eslami, Elisa Konofagou, Babak Baseri, Stephane Carlier, Andreas Koenig, Nassir Navab, Andrew Laine "Iterative Self-Organizing Atherosclerotic Tissue Labeling in Intravascular Ultrasound Images and Comparison with Virtual Histology", IEEE Transactions on Biomedical Engineering, 2012
  • Xin (Sheena) Liu, C. Imielinska, J. Kender, Andrew F Laine "Automatic Misalignment Correction of Neuroimages using Surface Symmetry Priors", Journal of Neuroimaging, vol. 21, doi: 10.1111/j.1552-6569.2011.00577.x, 2011
  • Qi Duan, Elsa Angelini, Andrew F Laine "Surface Function Actives", J. Vis. Commun. Image R., vol. 20, no. 7, pp. 478-490, 2009.
  • Noah Lee, Andrew F Laine, G. Marquez, J. M. Levsky, J. K. Gohagan, "Potential of Computer-Aided Diagnosis to Improve CT Lung Cancer Screening", IEEE Reviews in Biomedical Engineering, vol. 2, pp. 136-146, 2009.
  • Qi Duan, Elsa Angelini, S. Herz, C. Ingrassia, K. Costa, J. Holmes, Shunichi Homma, Andrew F Laine "Region-Based Endocardium Tracking on Real-Time Three-Dimensional Ultrasound", Ultrasound in Medicine and Biology, Vol. 35, No. 2, pp. 256-265, 2008
  • Konstas, J. Pile-Spellman, Matt Neimark, Andrew F Laine "A theoretical model of selective cooling using intracarotid cold saline infusion in the human brain", Journal of Applied Physiology, Vol. 102, pp. 1329–1340, 2007.
  • Jerome Kalifa, Andrew F Laine, Peter Esser "Regularization in Tomographic Reconstruction Using Thresholding Estimators", IEEE Transactions on Medical Imaging, Volume: 22 Issue: 3, March 2003 pp: 351-359, 2003
  • Ralf Mekle, Andrew F Laine, Edward Wu "Combined MR Data Acquisition of Multicontrast Images Using Variable Acquisition Parameters and K-Space Data Sharing", IEEE Transactions on Medical Imaging, Vol. 22, No. 7, pp. 806-823, 2003