This year, the Blavatnik Acceleration Fund at Columbia Engineering will support four teams researching bladder cancer, embryonic brain development, spontaneous preterm birth, and the basis of common language disorders. These awards are supported by the School’s Blavatnik Fund for Engineering Innovations in Health, made possible with the generous support from the Blavatnik Family Foundation, headed by Columbia Engineering alumnus Len Blavatnik MS’91. 

Established in 2018, the Blavatnik Fund for Engineering Innovations in Health focuses on research at the intersection of engineering and health, with the aim to expedite the development, application, and commercialization of breakthrough discoveries. 

The fund has supported 24 projects across seven cohorts, teams rooted in cross collaboration. Those investigations have led to breakthroughs in understanding the foundations of memory, enabled the development of an important new technique for stem cell therapy, and supported the construction of a prototype robotic walker that helps children with cerebral palsy learn to walk. 

In addition to sponsoring research projects, the Blavatnik Fund for Engineering Innovations in Health also supports talented doctoral students at a critical stage in their research. Since its inception in 2018, the Blavatnik Doctoral Fellowships have been awarded to 39 students across a range of areas of study–from biomedical optics to single-cell genomics and protein engineering to cutting-edge drug delivery.

The interdisciplinary nature of the research projects supported by the Blavatnik Fund for Engineering Innovations and Health underscores the Engineering School’s strong ties with collaborators at Columbia University Irving Medical Center, including the Vagelos College of Physicians and Surgeons, all working towards a common goal of bringing innovative solutions to engineering and medicine.

About the winning projects: 

Engineering tumor painting nanoparticles to promote immunotherapy responsiveness in bladder cancer

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PIs: Santiago Correa, assistant professor of biomedical engineering and member of the Herbert Irving Comprehensive Cancer Center; Nicholas Arpaia, associate professor of microbiology & immunology 

This project introduces a highly innovative strategy to enhance immunotherapy for muscle-invasive bladder cancer (MIBC) through the use of tumor 'painting' nanoparticles. These nanoparticles are designed to deliver immunomodulatory proteins directly to tumors via intravesical administration, meeting the urgent need for safer and more effective treatments. 

With MIBC's grim prognosis (~50% 5-year survival rate) and the limited success of current immunotherapies, their project aims to make tumors more responsive to such therapies, potentially benefiting a larger group of patients. Their research is structured around two main objectives. Aim 1 is to demonstrate that these nanoparticles can precisely target and deliver their protein payloads to MIBC tumors in advanced orthotopic mouse models, evaluating the treatment's efficacy and safety. Aim 2 explores the therapeutic potential of using these nanoparticles to deliver the CXCL13 chemokine, thereby priming the tumor microenvironment to enhance the response to PD-1 checkpoint blockade immunotherapy. The researchers hypothesize that CXCL13 delivery will induce the formation of tertiary lymphoid structures, known to amplify anti-cancer immune responses, as evidenced by recent MIBC clinical trials.

Their proposal integrates cutting-edge nanomedicine with immunology to offer a novel approach that could reduce treatment toxicity, target tumors more precisely, and amplify the effectiveness of existing cancer treatments. 

The genomic and synaptic basis of learned sound association and language disorder

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PIs: David Knowles, assistant professor of computer science and member of the Data Science Institute; David Sulzer, professor of psychiatry, neurology, pharmacology

Learned sound association is the process by which the auditory nervous system associates a sound with a certain outcome. This ability can be impaired in neurodevelopmental conditions such as language disorder and autism spectrum disorder (ASD). 

In this research project, Knowles and Sulzer aim to identify variants and genes affecting language disorder and study the neuronal pathways and circuits involved in sound association along with the mutations that can disrupt them. This will be achieved by using computational approaches to analyze large-scale human genetic data such as genome-wide association studies (GWAS) and post-GWAS analysis methods, and conducting behavioral experiments with fiber photometry in wildtype and mutant mice models using an interactive virtual reality environment.

A multi-omic investigation of the vaginal ecosystem and cervical biomechanical properties in pregnancy

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PIs: Kristin Myers, associate professor of mechanical engineering; Tal Korem, assistant professor of systems biology and reproductive sciences in Obstetrics and Gynecology; Mirella Mourad, assistant professor of obstetrics and gynecology 

Spontaneous preterm birth (sPTB) is one of the leading causes of complications during pregnancy, but there are few ways for physicians to predict or prevent it. Researchers have found that two factors — the community of bacteria living in the vagina and physical changes to the cervix — play a role in sPTB. 

With support from the Blavatnik Acceleration Fund, this research team will investigate how the vaginal ecosystem affects the stiffness of the cervix and its mechanical changes during pregnancy. This comprehensive approach could lead to new ways to identify women at risk of preterm birth and develop treatments to strengthen the cervix and prevent early labor.

Mechanobiology of early embryonic brain development

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PIs: Nandan Nerurkar, assistant professor of biomedical engineering; Maria Tosches, assistant professor of biological sciences

Errors in the earliest stages of brain development can lead to severe neurological disorders, but researchers still don’t fully understand the factors that determine how the embryonic brain’s shape and structure are formed. 

With support from the Blavatnik Acceleration Fund, this research team will study how physical forces and genetic signals work together to shape the developing brain. By combining engineering techniques to measure mechanical forces with advanced molecular biology methods, they aim to uncover how tension in the developing brain influences cell growth and identity.

This interdisciplinary approach could reveal fundamental insights into brain development, helping researchers understand how early disruptions can lead to neurological disorders and potentially guiding future treatments.

We know air pollution is a global problem. Are there particular areas in the world where it’s worse? Is it just around cities or is it spreading beyond?

Air pollution is a global problem. Today, air pollution levels are the most severe in areas of the Global South that are undergoing rapid economic development while at the same time developing air quality management strategies.

For the Clean Air Toolbox, you are the lead in India, and Dan Westervelt is the co-lead in Africa. What are you focused on now as part of this initiative?

Although our initiative is interdisciplinary and not only tech-focused, a lot of our most impactful work keeps coming back to data. A lack of data can hold back progress towards clean air at several stages of the process. In several African countries where Dan is working, there was previously little to no data on the ground that characterized background air pollution levels. Without that information, you can’t quantify the cost of inaction in order to motivate investment in clean air or evaluate whether actions taken locally are actually having an impact.

In India, our work is extending the government monitoring network that has been growing since 2016 to provide neighborhood-level information and insights into priority sources. Side by side with our technical work, we are working to build local capacity in air quality science and air quality management, and helping to establish a knowledge base of best practices for getting high-value, trustworthy data from low-cost sensors.

What about other areas of the world? 

The Clean Air Toolbox is focusing on cities in the Global South so we hope to include South America someday. Dan and I do more U.S.-focused work in our other research: for example, Dan has been measuring air quality around New York City and Columbia’s Lamont-Doherty Earth Observatory, and I have collaborations with the U.S. EPA focused on improving their air quality modeling.

The Clean Air Toolbox Columbia faculty aren’t just scientists and engineers they’re lawyers, doctors, and policymakers, too. How is the group working together?

The work our group does crosses disciplinary boundaries the scientists are deeply involved in policy discussions and public health and policy specialists are helping design air pollution data collection, and we are all working with our local partners to build their capacity. Specific examples of contributions outside engineering and air quality science include work by members of our group from the Sabin Center for Climate Law who have done analyses of environmental laws in India to look for opportunities for the Kolkata Municipal Corporation to contribute to air pollution reduction. We also have several members from the Mailman School of Public Health who look at connections between air pollution exposure and health outcomes in women and children in Ghana, India, and elsewhere. And some of our group members have developed economic strategies to encourage the adoption and sustained use of clean cookstoves. The close collaborations that have formed among Clean Air Toolbox researchers with completely different disciplinary viewpoints have been both productive and rewarding, and make me think differently about my research priorities.

What have been some of the successes out of this collaboration to date? 

Our work has generated the first air pollution data from highly populated cities such as Kinshasa, Democratic Republic of the Congo. We are leading the state of the science in low-cost sensor applications, building relationships with local decision makers and informing policy in India, and increasing capacity among thousands of local practitioners on air quality management and air pollution science. 

How can we as individuals contribute to improving air quality while combating climate change?

Making choices to use public transportation, for example, can definitely help reduce emissions and contribute to cleaner air. However, systemic changes such as transitioning to cleaner energy for electric power and industry are also needed for major change. 

What continues to inspire and motivate your work in air quality and climate change?

Air quality is a problem that affects everyone who breathes air, which is to say, all of us! I personally have asthma, and so does my son, so I have experienced this issue in a way that is more personal and immediate than many have. The health burden of air pollution is borne disproportionately by women, children, and those of lower socioeconomic status worldwide. I think that all humans have a right to breathe clean air, and I hope our work pushes things in this direction.

Are you optimistic about the future?

I am optimistic about clean air in the future. In my lifetime we’ve seen major improvements in air quality in the U.S., thanks to the Clean Air Act and subsequent amendments. China invested heavily in addressing their environmental issues throughout the 2010s and things are turning the corner there. We are also seeing changes in India and across the African continent since 2019 when we founded the Clean Air Toolbox, and there are a lot of exciting opportunities for cities and countries in the Global South to learn from one another’s success stories.

About the Study

Journal: Nature Cardiovascular Research

The study is titled “An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury.”

Authors are: Sharon Fleischer1,*, Trevor R. Nash1,*, Manuel A. Tamargo1, Roberta I. Lock1, Gabriela Venturini2, Margaretha Morsink1, Pamela L. Graney1, Vanessa Li1, Morgan J. Lamberti1, , Martin Liberman1, Youngbin Kim1, Daniel N. Tavakol1, Richard Z. Zhuang1, Jaron Whitehead1, Richard A. Friedman3,4, Rajesh K. Soni5, Jonathan G. Seidman2, Christine E. Seidman2,6,7, Laura Geraldino-Pardilla8, Robert Winchester8,9 and Gordana Vunjak-Novakovic1,8,10,‡

1Department of Biomedical Engineering, Columbia University, New York, NY, USA

2Department of Genetics, Harvard Medical School, Boston, MA, USA

3Biomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA

4Department of Biomedical Informatics, Columbia University, New York, NY, USA

5Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA

6Division of Cardiovascular Medicine, Brigham and Women’s Hospital & Harvard Medical School, Boston, MA, USA

7Howard Hughes Medical Institute, Chevy Chase, MD, USA

8Department of Medicine, Columbia University, New York, NY, USA

9Columbia Center for Translational Immunology, Columbia University College of Physicians and Surgeons, New York, NY, USA

10College of Dental Medicine, Columbia University, New York, NY, USA

The study was supported by. National Institutes of Health (P41EB027062 and 3R01HL076485 to G.V-N.), the American Heart Association (19TPA34910217 to R.W.), a Pfizer Aspire research award (WI237809 2018 ASPIRE US Rheumatology to R.W.), and the National Science Foundation (NSF1647837 to G.V-N.).

The authors declare no financial or other conflicts of interest.

Three Things to Know about Microplastics and Nanoplastics

1. Ubiquitous Presence

   Microplastics, tiny particles less than 5 millimeters in size, have been found in environments worldwide—from the deepest parts of the ocean to the Arctic ice, and even in the air we breathe and the food we consume. In environments, microplastics can continue to break down, and form nanoplastics, plastic particles with sizes less than 1 micrometer. 
    

2. Hidden in Plain Sight

   A recent study by Dr. Yan has revealed that bottled water can contain hundreds of thousands of nanoplastic particles per liter. These tiny bits are often invisible to the naked eye but can be ingested by humans and animals, potentially impacting health.
    

3. Persistent Pollutants

   Microplastics are highly resistant to environmental degradation. They can linger in ecosystems for decades, accumulating and posing long-term risks to marine life and food safety as they absorb and concentrate toxic pollutants. Due to the small particle size, nanoplastics can enter the human body and transport to vital organs such as the liver, potentially leading to negative health outcomes. The funded NOAA project will build smart plastic collection systems, and if successful, can largely reduce the riverine input to ocean environments.