ABOUT THE STUDY

JOURNAL: Nature Materials

TITLE: "Integrated internal ion-gated organic electrochemical transistors for stand-alone conformable bioelectronics"

AUTHORS: Claudia Cea(†1), Zifang Zhao(†1), Duncan J. Wisniewski(1), George D. Spyropoulos(1§), Anastasios Polyravas(1), Jennifer N. Gelinas(*2,3), Dion Khodagholy(*1)

1. Department of Electrical Engineering, Columbia University, New York, NY 10027, USA
2. Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
3. Institute for Genomic Medicine, Columbia University Medical Center, 630 W 168th St. New York, NY 10032, USA

§ Current address: Department Information Technology, Waves, UGhent Technology Campus, iGhent, Technologiepark 126, 9052 Zwijnaarde, Belgium

FUNDING: This work was supported by the National Institute of Health grants R01NS118091, R21 EY 32381-01, and RF1NS128669, National Science Foundation 1944415 and 2219891, and the Odysseus program from the Research Foundation – Flanders (FWO) G0F9421N.

The authors declare no financial or other conflicts of interest.

About the Study

Journal: Nature Human Behaviour

Study title: “Neuronal activity in the human amygdala and hippocampus enhances emotional memory encoding.”

Authors: Salman Ehtesham Qasim (Department of Psychiatry, Icahn School of Medicine at Mount Sinai), Uma Rani Mohan (Surgical Neurology Branch, NINDS, National Institutes of Neurological Disorders and Stroke), Joel Stein (Department of Radiology, University of Pennsylvania), and Joshua Jacobs (Departments of Biomedical Engineering, Neurological Surgery, Columbia University). Both Qasim and Mohan were graduate students in Joshua Jacobs’ lab at Columbia Engineering when beginning this project.

This work was supported by NIH grants U01-NS113198 and R01-MH104606.

COI: The authors declare no financial or other conflicts of interest.

About the Study

JOURNAL: Nature Genetics

STUDY: “Multi-modal single-cell and whole-genome sequencing of small, frozen clinical specimens.”

AUTHORS: Yiping Wang (1,2*), Joy Linyue Fan (3*), Johannes C. Melms (1,4*), Amit Dipak Amin (1,4), Yohanna Georgis (5), Irving Barrera (6), Patricia Ho (1,4), Somnath Tagore (1,7), Gabriel Abril-Rodriguez(8), Siyu He (3), Yinuo Jin (3), Jana Biermann (1,2), Matan Hofree (6), Lindsay Caprio (1,4), Simon Berhe (4), Shaheer A. Khan (1,5), Brian S. Henick (1,5), Antoni Ribas (8,9), Evan Z. Macosko (6,10), Fei Chen (6,11), Alison M. Taylor (5,12), Gary K. Schwartz (1,5), Richard D. Carvajal (1,5), Elham Azizi (3,5,13,#), Benjamin Izar (1,2,4,5,7#)

1. Department of Medicine, Division of Hematology/Oncology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
2. Department of Systems Biology, Program for Mathematical Genomics, Columbia University
3. Department of Biomedical Engineering, Columbia University
4. Columbia Center for Translational Immunology, Columbia University Irving Medical Center
5. Vagelos College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Columbia University
6. Broad Institute of Harvard and MIT
7. Department of Systems Biology, Columbia University Irving Medical Center
8. Department of Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles (UCLA)
9. Parker Institute for Cancer Immunotherapy, San Francisco
10. Department of Psychiatry, Massachusetts General Hospital
11. Department of Stem Cell and Regenerative Biology, Harvard University
12. Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA
13. Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA.

FUNDING: Y.W. is supported by National Institutes of Health (NIH), National Institute of Allergy and Infectious Disease training grant (no. T32AI148099). B.I. is supported by the NIH, National Cancer Institute (NCI) (grant nos. K08CA222663, R37CA258829, R01CA266446, and U54CA225088), a Burroughs Wellcome Fund Career Award for Medical Scientists, a Velocity Fellows Award, the Louis V. Gerstner, Jr. Scholars Program and a Young Investigator Award by the Melanoma Research Alliance. R.D.C., E.A., and B.I. are supported by an NCI grant (no. R21CA263381) and a Columbia University Research Initiatives in Science & Engineering Award. E.A. was supported by an NCI grant (no. R00CA230195) and NSF grant (no. CBET-2144542). J.L.F. acknowledges support from the Columbia University Van C. Mow fellowship. G.A.-R. and A.R. are supported by the Parker Institute for Cancer Immunotherapy and an NIH grant (no. P01CA168585). A.M.T. is supported by the NCI (grant no. 5K22CA237733-03). This work was supported by an NIH/NCI Cancer Center Support grant (no. P30CA013696), the Molecular Pathology Shared Resource and its Tissue Bank at Columbia University, and the Flow-cytometry Core Facility supported by a grant (no. S10OD020056).

COI: B.I. has received consulting fees from Volastra Therapeutics Inc, Merck, AstraZeneca, and Janssen Pharmaceuticals and has received research funding to Columbia University from Alkermes, Arcus Biosciences, Checkmate Pharmaceuticals, Compugen, Immunocore, and Synthekine. G.A.-R. has received honoraria from consulting with Arcus Biosciences. A.R. has received honoraria from consulting with Amgen, Bristol Myers Squibb, Chugai, Genentech, Merck, Novartis, Roche, and Sanofi, is or has been a member of the scientific advisory board, and holds stock in Arcus, Compugen, CytomX, Highlight, ImaginAb, Isoplexis, Kite-Gilead, Lutris, Merus, PACT, RAPT, Synthekine, and Tango Therapeutics. A.M.T. receives research support from Ono Pharmaceuticals. B.S.H. participated in advisory boards for AstraZeneca and Ideaya. R.D.C. is a consultant for Alkermes, Bristol Myers Squibb, Castle Biosciences, Delcath, Eisai, Hengrui, Ideaya, Immunocore, InxMed, Iovance, Merck, Novartis, Oncosec, Pierre Fabre, PureTech Health, Regeneron, Sanofi Genzyme, Sorrento Therapeutics and Trisalus, serves on clinical/scientific advisory boards for Aura Biosciences, Chimeron, and Rgenix Research, and has received research funding to Columbia University from Amgen, Astellis, AstraZeneca, BioMed Valley, Bolt, Bristol Myers Squibb, Corvus, Cstone, Foghorn, Ideaya, Immatics, Immunocore, InxMed, Iovance, Merck, Mirati, Novartis, Pfizer, Plexxikon, Regeneron, and Roche/Genentech. B.I. and J.C.M. filed a patent describing the generation of high-quality single-cell genomics data from frozen tissues. The remaining authors declare no competing interests.